Policy Title: Assignment of Protocols to UW-Madison ACUCs
POLICY: Protocols are assigned to ACUCs for review/approval based on animal housing locations except when research procedures are, in the opinion of the Chief Campus Veterinarian or designee, of a nature or duration that oversight by the ACUC responsible for the procedure or procedure site is more appropriate.
In most cases the review/approval and post-approval monitoring is carried out by a single ACUC. There is no regulatory requirement for duplicative IACUC review and approval of animal care and use protocols. However, for purposes of information-sharing and animal program consistency, it may be appropriate at times for members of multiple UW-Madison ACUCs to be involved in the review of protocols that involve animal activities that cross ACUC oversight areas.
The assignment of protocols to UW-Madison ACUCs and oversight will be managed as follows:
- When all of the animals are housed in facilities that fall within the oversight of a single ACUC, that ACUC will review, approve, and oversee the animal protocol. Upon determination of the Chief Campus Veterinarian or designee, a protocol will instead be assigned to the ACUC with oversight of a procedure, or procedure site or sites, and that ACUC will review, approve, and oversee the animal protocol.
- If animals are housed in facilities that fall within the oversight of more than a single ACUC, the Chair and Senior Program Veterinarian (SPV) of the involved ACUC(s) will be provided a copy of the protocol by RARC IACUC office staff during the initial review phase for review. The Chair and SPV have four options:
- Relegate review/approval to the primary ACUC;
- Relegate review/approval to the primary ACUC and provide written (email) review input to be considered by the primary ACUC in reviewing the protocol;
- Relegate review/approval to the primary ACUC with the Chair and/or SPV, or their designee(s), serving as consultants to the primary ACUC in reviewing the protocol;
- Require review of the protocol at a joint meeting of all involved ACUCs.
- If research procedures are conducted on animals in locations that fall within the oversight of more than a single ACUC, the RARC IACUC office will route the protocol to the Chair and SPV as described above in (2). The Chair and SPV may exercise the same four options as detailed above.
- Any ACUC may involve consultants (e.g., the Chair or SPV of another ACUC) as allowed by the Animal Welfare Act 2.31(d)(3)* in the review of protocols.
- If an amendment to or three-year renewal of an active protocol is submitted and expands the ACUC oversight to involve a second or additional ACUCs, the amendment/renewal will be managed as described in (2) and (3) above.
- Intracampus coordination of ACUC-approved activities with animals must occur outside of the ACUC review process.
- In cases of relegated review (see point 2 above), the ACUC to which the protocol is relegated is responsible for postapproval monitoring activities, review/approval of protocol amendments, and annual reviews of that protocol. In cases in where more than one ACUC is involved in a protocol review and approval, all ACUCs are responsible for post-approval monitoring activities and annual reviews of the protocol. A joint meeting will need to be held each and every time the protocol is amended unless such amendment removes the oversight responsibilities of an ACUC.
* 2.31(d)(3) The IACUC may invite consultants to assist in the review of complex issues arising out of its review of proposed activities. Consultants may not approve or withhold approval of an activity, and may not vote with the IACUC unless they are also members of the IACUC.
Author: S. Boehm, H. McEntee, R. Lane, H. McEntee, R.Streiffer
ePublication Date: 2003-10-31 (orig.)
History: 12/2010, 2/2012, 9/2012, 1/2014, 7/2015