Policy Number: 2010-037-io
Policy Title: Policy on the Use of Nonpharmaceutical-Grade Compounds in Research Animals

POLICY:

Pharmaceutical-grade compounds should be used, when available, for all animal-related activities. Principal Investigators must describe and scientifically justify the use of non-pharmaceutical-grade substances in an animal use protocol, which must be approved by the appropriate Animal Care and Use Committee.

For the purposes of this policy, pharmaceutical-grade compounda include:

FDA-approved veterinary or human compounds specifically formulated for clinical application

Veterinary or human pharmaceutical compounds listed in the:

  • United States Pharmacopeia (USP)
  • USP-National Formulary (USP-NF)
  • British Pharmacopeia (BP)
  • European Pharmacopeia (EP)

Read guidance for protocol justification for the use of non-pharmaceutical compounds

Read guidance in preparing and storing non-pharmaceutical compounds

Read SOP for mixing sodium pentobarbital for anesthesia

Read SOP for mixing sodium pentobarbital for euthanasia

Read SOP for mixing MS-222

Read SOP for mixing urethane

Read SOP for mixing tribromoethanol

References:


Author: H. McEntee, J. Welter, D. Jefcoat, D. Uhlrich, B. Darien, R. Stoffel, RARC Veterinary Staff, R. Colman
ePublication Date: 4/9/2010
History: amended 2012-06-01; 2014-10-03; 2017-09-08