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Policy Number: 2010-037-io
Policy Title: Policy on the Use of Nonpharmaceutical-Grade Compounds in Research Animals
Policy: Pharmaceutical-grade compounds should be used, when available, for all animal-related activities. Principal Investigators must describe and scientifically justify the use of non-pharmaceutical-grade substances in an animal use protocol, which must be approved by the appropriate Animal Care and Use Committee.

For the purposes of this policy, pharmaceutical-grade compounda include:

FDA-approved veterinary or human compounds specifically formulated for clinical application

Veterinary or human pharmaceutical compounds listed in the:

  • United States Pharmacopeia (USP)
  • USP-National Formulary (USP-NF)
  • British Pharmacopeia (BP)
  • European Pharmacopeia (EP)

Read guidance for protocol justification for the use of non-pharmaceutical compounds

Read guidance in preparing and storing non-pharmaceutical compounds

Read SOP for mixing sodium pentobarbital for anesthesia

Read SOP for mixing sodium pentobarbital for euthanasia

Read SOP for mixing MS-222

Read SOP for mixing urethane

Read SOP for mixing tribromoethanol

References:
  1. The Guide for the Care and Use of Laboratory Animals, 8th ed., 2011
  2. USDA Animal Care Policy Manual, 2016
  3. OLAW/USDA/AAALAC International webinar "Use of Non-Pharmaceutical-Grade Chemicals and Other Substances in Research with Animals"
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