Animal Program: Use of Nonpharmaceutical-Grade Compounds

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Policy Number:
UW-4123
Old Policy Number:
2010-037-io
Responsible Office:
Research Animal Resources and Compliance

University Policy

Policy:
  1. Pharmaceutical-grade compounds should be used, when available, for all animal-related activities.
  2. Principal investigators must describe and scientifically justify the use of non-pharmaceutical-grade substances in an animal use protocol, which must be approved by the appropriate Animal Care and Use Committee (ACUC).
  3. For the purposes of this policy, pharmaceutical-grade compounds include:
    1. U.S. Food and Drug Administration (FDA) approved veterinary or human compounds specifically formulated for clinical application.
    2. Veterinary or human pharmaceutical compounds listed in the:
      1. United States Pharmacopeia (USP).
      2. USP-National Formulary (USP-NF).
      3. British Pharmacopeia (BP).
      4. European Pharmacopeia (EP).
  4. Resources:
    1. Guidance for protocol justification for the use of non-pharmaceutical compounds
    2. Guidance in preparing and storing non-pharmaceutical compounds
    3. Standard operating procedure (SOP) for mixing sodium pentobarbital for anesthesia
    4. SOP for mixing sodium pentobarbital for euthanasia
    5. SOP for mixing MS-222
    6. SOP for mixing urethane
    7. SOP for mixing tribromoethanol
Related UW–Madison Documents, Web Pages, or Other Resources:
External References:

Policy Administration

Approval Authority:
Associate Vice Chancellor of Research Policy and Compliance
Policy Manager:
Associate Vice Chancellor of Research Policy and Compliance
Contact:
IACUC Administrator -- IACUC Administrator, iacuc_administrator@rarc.wisc.edu, (608) 262-1238
Effective Date:
04-09-2010
Date Issued:
04-09-2010
Revised Dates:

06-01-2012, 10-03-2014, 09-08-2017, 10-12-2021

Retrieved:
04-24-2024 21:02:39