Rodent Analgesia Service
- RARC Veterinary Service Agreement
- RARC Dose Pricing Chart
- Buprenorphine Dosing Presentation by Dr. Becky Johnson
In some instances RARC Veterinary Services (RARC VS) may be able to provide extended release buprenorphine to your rodent models. RARC VS charges a fee for this optional service.
Charges for rodent analgesia provided by RARC VS:
Veterinary Technician Charge: $40.00/hour (billed in 15 minute increments, minimum billing time 1 hour).
Charges are based on the weight of animal: see dose pricing chart for details. Prices are subject to change based on vendor pricing and availability.
What you receive:
- RARC VS will meet with you in advance to determine an initial dosing schedule for providing analgesia to your rodents.
- RARC VS will dose your rodents with an analgesic either in your laboratory space or in the vivarium.
- In most cases RARC VS provides an analgesia that is a formulation of sustained or extended-release buprenorphine.
- RARC VS will give buprenorphine pre-procedure in cases when surgical analgesia is requested.
- You must describe all procedures and subsequent analgesia (i.e. sustained release buprenorphine) in your animal-use protocol. See language below.*
- The PI/research staff is responsible for monitoring all animals post-procedure as per your approved protocol.
Any signs of pica (eating of bedding or nesting material) or inappetence must be reported to your veterinary staff promptly.
- The PI/research staff is responsible for any noncontrolled substance analgesia that rodents may require in addition to the analgesic given by RARC VS.
- Analgesic services are only available non-holiday weekdays during regular business hours (7:30 a.m. to 3 p.m.). Analgesic administration should be timed so that all dosing is completed no later than 3 p.m.
- You must clearly mark the cages of all animals receiving RARC analgesia services.
- The PI/ research staff is responsible for any sign-ups for shared equipment (e.g. bio-safety cabinets in shared spaces) required during the time of procedure and/or time of analgesic administration.
- Please mail the completed RARC Veterinary Service Agreement to firstname.lastname@example.org. We will review the details of your request and set up a meeting, if needed. Note: your signature isn't required on the form until we meet with you.
*Add the following information to the Anesthesia/Analgesia/Sedation section of your protocol:
|Drugs and Compounds||Buprenorphine Sustained Release (1mg/mL)|
|Description||Rat - 1.2 mg/kg SC into the scruff q48h
Mouse - 0.6 mg/kg SC into the scruff q48h
|Monitoring Plan||Animals will be monitored once daily for three days to ensure adequate analgesia. (If buprenorphine will be used in conjunction with a surgical procedure, describe the surgery monitoring here as well.)|
Add the following information to the Complications section of your protocol:
Potential complications for Buprenorphine SR Lab:
- Rodents may (or may not) experience a reaction at the injection site.
- Rodents may exhibit pica or self-gnawing and licking behaviors and require alternate types of bedding and/or supportive care at the discretion of the RARC veterinarian for the duration of treatment. (Do not keep animals on wood chip or corncob bedding if pica is observed after administration).
- Mild weight loss has been observed post-procedurally in rodents administered opioids.
- Use with caution in rodents with preexisting respiratory deficiencies.