Rodent Analgesia Service

In some instances RARC Veterinary Services (RARC VS) may be able to supply extended release buprenorphine for your rodent models. RARC VS charges a fee for this service; your use of it is voluntary.

What You Receive:

  1. A member of the RARC VS staff will meet with you in advance to discuss this service and to determine an initial dosing schedule for providing analgesia to your rodents.
  2. A member of the RARC VS will dose your rodents with an analgesic either in your laboratory space or in the vivarium (dosing location will be determined at time of meeting).
    • In most cases the analgesia that will be provided will be a formulation of sustained or extended- release buprenorphine.
    • Depending on study design it will be determined if the buprenorphine will be given pre/post-procedure.

PI Requirements:

  1. All procedures to be conducted and subsequent provided analgesia (i.e. sustained release buprenorphine) must be described and approved in your animal use protocol.

    Add the following information to the substance admin: analgesic/anesthetic/sedation section of your protocol:

    Regimen: Buprenorphine SR™LAB
    Drugs and Compounds
    Buprenorphine Sustained Release (1mg/mL)
    Description: Rat – 1.0-1.2 mg/kg SC into the scruff q72h
    Mouse 0.5-1.0 mg/kg SC into the scruff q72h
    Monitoring Plan: Animals will be monitored once daily for 3 days post buprenorphine injection to look for skin reaction. (If buprenorphine will be used in conjunction with a surgical procedure, describe the surgery monitoring here as well.)
    Regimen: Animalgesics® for Mice & Rats
    Drugs and Compounds
    Buprenorphine HCl extended-release injectable suspension (1.3 mg/mL)
    Description: Rat – 0.65 mg/kg SC into the scruff q48-72h
    Mouse 03.25 mg/kg SC into the scruff q48-72h
    Monitoring Plan: Animals will be monitored once daily for 3 days post buprenorphine injection to look for skin reaction. (If buprenorphine will be used in conjunction with a surgical procedure, describe the surgery monitoring here as well.)

    Add the following information to the complications section of your protocol:

    Potential complications for either formula:

    • A reaction at the injection site can occur in some strains of mice and rats.
    • Rats may exhibit pica or self-gnawing and licking behaviors and require alternate types of bedding and/or supportive care at the discretion of the RARC veterinarian for the duration of treatment. (Do not keep animals on wood chip or corncob bedding if pica is observed after administration of either formula.)
    • Weight loss has been observed in mice treated postprocedurally with Animalgesics for Mice.
    • Do not use on mice or rats with preexisting respiratory deficiencies.
  2. The PI/research staff is responsible for monitoring all animals post-procedure as per your approved protocol.
    • Any signs of pica (eating of bedding or nesting material) or inappetence must be reported to your veterinary staff promptly.
  3. The PI/research staff is responsible for any non-controlled substance analgesia that rodents may be required in addition to the analgesic given by RARC VS.
  4. Analgesics will only be supplied during normal RARC business hours M-F 7:30am-4pm. For dosing all procedures must be started (preoperative dosing) or completed (post-operative dosing) no later than 3pm to allow for adequate time of analgesic administration.
  5. The cages of all animals receiving RARC analgesia services must be clearly marked.
  6. The PI/ research staff is responsible for any sign-ups for shared equipment (e.g. bio-safety cabinets in shared spaces ) required during the time of procedure and/or time of analgesic administration.
  7. Please mail the completed Rodent Analgesia Agreement to rodentanalgesia@rarc.wisc.edu. We will review the details of your request and set up a meeting, if needed. Note: your signature isn't required on the form until we meet with you.

Charges:

  1. Charges for Rodent Analgesia Provided by RARC VS are as follows:
    • Technician Charge: $40.00/hour (billed in 15 minute increments, minimal billing time 1 hour).
    • Dose Charge: $1.00 per mouse and $7.50 per rat.