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Researchers must obtain approval before changing drugs, procedures, or animals
The protocol is a contractual agreement between a principal investigator and the IACUC, an agent of the USDA and OLAW. Any and all changes to procedures or tests performed on animals, substances administered to animals, or the species or number of animals to be used, must be approved before the changes are carried out by the researcher.

Changes that don't require an amendment or IACUC approval
Changes to personnel (other than the PI) and funding are called "Non-review Changes" and do not require IACUC approval, but must be changed in the protocol. Get detailed instructions for making Non-review Changes

Changes that require an amendment and IACUC approval
Significant changes such as changing the PI, increasing animal pain and distress, or increasing the hazard risks to personnel or animals require an amendment and IACUC approval. Get detailed instructions for creating and submitting an amendment in ARROW

Changes eligible for approval via veterinary consultation only
Some significant changes may be eligible for Veterinary Verification and Consultation (VVC). These include adding or changing anesthetic or analgesic regimens, adding or changing species-appropriate euthanasia methods, or requesting additional animals. See policy 2016-058-c or contact your veterinarian to discuss this possibility.

Performing work that is not described in an IACUC-approved protocol is a serious violation of animal welfare regulations. See more information on consequences here.

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